First record of VKORC1 sequence mutation associated with resistance to anticoagulant rodenticides in Italian individuals of Mus musculus domesticus
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Department of Biology, University of Florence, via Madonna del Piano 6, 50019 Sesto Fiorentino (FI), Italy
Latium Region, Natural Capital, Parks and Protected Areas, viale del Tintoretto 432, 00142 Rome, Italy
Nature and Environment Management Operators Srl (NEMO), Piazza Massimo D’Azeglio 11, 50121 Florence, Italy
Publication date: 2019-10-11
Corresponding author
Sara Fratini   

University of Florence
Hystrix It. J. Mamm. 2019;30(2):183-185
Non-synonymous mutations in the gene encoding vitamin K epoxide reductase (VKORC1) are responsible for resistance to anticoagulant rodenticides in rodents. Detection of resistant individuals is crucial to implement effective management plans and guarantee the success of eradication campaigns. Resistant individuals of the house mouse Mus musculus have been reported in several European countries and in North America. However, to date no data is available for M. musculus domesticus in Italy. In this study, we sequenced the three exons of the VKORC1 gene in 30 mice from the Pontine Archipelago, currently subject to an eradication campaign of invasive rodents. We recorded the presence of a mutation known to confer resistance to rodenticides (Tyr139Cys) in one individual (3.3% of the total samples set). Our data represent the first record of a resistant M. musculus domesticus in Italy.
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